Oocyte excellent and range are important determinants of reproductive existence span and success. These variables are shaped partially by the elimination of oocytes that experience troubles in the early levels of meiosis. Meiotic prophase-I marks an extended duration of genome vulnerability in which epigenetic reprogramming unleashes retroelements and a huge selection of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination essential for precise chromosome segregation at the primary meiotic division. Expression of LINE-1 retroelements perturbs many aspects of meiotic prophase and is associated with oocyte Dying over the early phases of meiotic prophase I.
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